Adrafinil: Review of uses, dosage, and side effects

Looking for an in-depth adrafinil review?

Well, it’s time to stop looking, because you’ve found it!

This is a helpful guide to using and purchasing adrafinil, a research chemical that’s actually a metabolic prodrug of modafinil (which means that it’s converted to modafinil after ingestion).

Adrafinil is interesting because in the US it’s neither a supplement nor a drug. In most countries it’s treated as a research chemical, meaning you don’t need a prescription to purchase it. However, it’s only available for research purposes.

In this article we’re gonna deep dive into what it is, how it works, IF it works, its potential benefits and effects, the right dosage (including a little info about stacking it with other nootropics) and the best place to buy it online.

We even answer your most important questions, including:

• Is Adrafinil safe to take?

• How long does Adrafinil last?

• What are the best Adrafinil alternatives?

All of this stuff is super important to know if you’re planning on purchasing it.

Ready to learn more about adrafinil? Then read on!

P.S: Click here to order Adrafinil from the best vendor in the world!

Understanding the Mechanism of Action of Adrafinil

Adrafinil is a research chemical that’s nearly identical to modafinil in terms of its structure. In fact, it’s a prodrug of modafinil, meaning that your body metabolizes it into modafinil after ingestion.

Therefore, it potentially provides some of the same benefits and effects. Adrafinil’s original and primary use was as a eugeroic (wakefulness agent) for people with sleep disorders [1, 2].

Adrafinil was actually discovered before modafinil was, and beat modafinil to the prescription drug market by a few years as a prescription wakefulness agent in France. However, pharmaceutical companies quickly lost interest in adrafinil after the more powerful modafinil came on the scene.

Olmifon, the name brand of adrafinil, was manufactured until 2011, when it was discontinued.

However, adrafinil is still produced by other companies, and remains available for purchase in several countries where it was never classified as a prescription drug, including the United States.

Nootropics researchers are particularly interested in its nootropic, or brain-enhancing, benefits. Adrafinil may in fact provide some powerful cognition-boosting effects.

Adrafinil Benefits

Here are the top five nootropic benefits of adrafinil. It’s important to note that these benefits have mostly been seen in animal studies, as the available research on the effects of adrafinil in humans is very limited.

1. Alertness

Adrafinil is a wakefulness agent by design, and was originally developed as a prescription drug for people with sleep disorders. It may help you to stay more alert during the day [1].

Several animal studies have noted increases in alertness and activity after adrafinil administration, as well [3, 4, 5].

2. Energy

On a similar note, adrafinil may provide a more sustained level of energy throughout the day to help prevent fatigue or slumps.

Increased energy was its original purpose when it was marketed as a prescription drug in France, and many researchers have likewise reported that it increases energy levels [1].

3. Productivity

In several animal studies in aged beagles, mice, and rhesus monkeys, researchers have noted that adrafinil led to increases in locomotion, or movement and activity [3, 4, 5, 6].

Although results are mixed, most studies note this effect [7].

In humans, this could potentially translate to an increase in productivity. However, more research in humans is needed.

4. Performance

One small study in aged beagles investigated the effects of adrafinil on test performance [8].

Researchers found that adrafinil significantly improved their performance, reducing errors and the time it took the dogs to complete the task [8].

This data is derived from early animal research, but nonetheless it’s promising  research and provides some insight into how adrafinil may affect human subjects.

5. Learning

The same beagle study noted improvements in learning and information processing, which resulted in the dogs’ improved performance [8].

Given its potential to cause improvements in learning, memory, test-taking, and cognitive performance, adrafinil is a solid starting point for researchers interested in nootropics.

Adrafinil Side Effects

Adrafinil is generally considered to be a safe nootropic compound – especially when using the recommended dosages. However, like any supplement or medication, there are potential side effects that future Adrafinil users MUST be aware of.

Some of the most common side effects associated with Adrafinil use include:

• Headaches: Adrafinil may cause headaches or migraines in some users, especially when taken at larger doses.

• Nausea and Stomach Discomfort: Adrafinil can cause stomach discomfort and nausea. This can normally be alleviated by taking Adrafinil with food.

• Insomnia: The effects of Adrafinil last up to 10-15 hours in the body. If you take Adrafinil later in the day (not recommended), it may cause difficulty falling or staying asleep.

• Anxiety and Agitation: In rare cases, Adrafinil can cause anxiety and agitation. These are signs of a potential Adrafinil overdose.

It is important to monitor for these side effects when using Adrafinil and to discontinue use if any negative symptoms occur.

Fortunately, these side effects are rare, and most responsible Adrafinil users never experience them while using the nootropic.

Adrafinil Dosage Calculator and Chart

Anyone interested in using Adrafinil should familiarize themselves with the recommended dosage guidelines.

Here is a dosing calculator and chart to help you determine the appropriate Adrafinil dosage based on your weight and desired effects:

Dosing Calculator

To calculate your Adrafinil dosage, use the following formula:

• Body weight (in lbs) x 1-3 = recommended starting dosage (in mg)

For example, here are some sample calculations for individuals with different body weights:

• 150 lbs x 1-3 = 150 - 450 mg per day

• 200 lbs x 2 = 200 - 600 mg per day

• 250 lbs x 2 = 250 - 750 mg per day

For example, a person weighing 200 pounds would take anywhere from 200 - 600 mg of Adrafinil as their starting dose.

Dosing Chart

Truth be told, using an Adrafinil dosing chart can be a little bit confusing. Here are some general guidelines for low / medium / high Adrafinil doses:

• Low dose: 200 - 400 mg per day

• Moderate dose: 400 - 800 mg per day

• High dose: 800 - 1,200 mg per day

It’s important to note that higher doses of Adrafinil can increase the risk of negative side effects such as headaches, nausea, and liver toxicity.

It is recommended to start with a low dose and gradually increase as needed while monitoring for any negative symptoms.

Adrafinil Review | Does the Nootropic Actually Work?

Adrafinil is a popular nootropic compound that is known for its ability to enhance cognitive function and promote wakefulness.

But does it actually work? Here’s what you need to know…

Our Experience:

We have been using and testing Adrafinil for years, and we can confirm its powerful benefits for improved mood, focus, concentration, and overall cognitive performance.

We felt more productive while taking Adrafinil and able to tackle tasks with greater ease. Adrafinil sometimes feels like a real “Limitless Drug,” where you are in the zone and operating at your maximum potential.

We also experienced virtually zero side effects while using Adrafinil. Other benefits that we experienced included:

• Decreased mental fatigue

• Euphoric-like feeling while working

• Ability to concentrate for hours

• Increased creativity

• Decreased stress levels

Adrafinil works so well for us, that we continue to use it whenever we are busting out a long work day and need to perform at our absolute best.

User Reviews:

A quick search online reveals thousands of high-performing individuals who are getting incredible results from Adrafinil. Most users are raving about they feel while using Adrafinil – especially while performing difficult work tasks.

Here is what one new Adrafinil user had to say about the product:

“Adrafinil is a game-changer for me. I used to struggle with fatigue and brain fog all the time, but since I started taking Adrafinil, I have so much more energy and mental clarity. It’s not a magic pill – I still have to put in the work – but it definitely helps me stay focused and productive. I’m so glad I discovered this product!” - Robert N.

Overall, most users are blown away by the effects of Adrafinil. As long as you take it first thing in the morning, you can expect all-day energy and unbelievable cognitive performance.

Forms of Adrafinil

Adrafinil is available in a few different forms, each with its own advantages and disadvantages. Here are the most common forms of Adrafinil:

• Capsules: Capsules are the most popular and easiest to use form of Adrafinil. They come pre-measured with precise Adrafinil doses, making it easy to take your target dose.

• Powder: Adrafinil powder is significantly cheaper than Adrafinil capsules, and a great option for advanced users who want to save money and use customized dosing protocols.

• Liquid: Adrafinil liquid is a fast and convenient way to take this nootropic. It can be added to water or taken directly under the tongue for faster absorption.

Overall, Adrafinil capsules are the most popular form and ideal for new Adrafinil users. However, Adrafinil powders and liquids are also viable options as well.

Where To Buy Adrafinil Online?

By now you’re probably wondering where to purchase high-quality Adrafinil online. Our team of experts has personally tested every major online Adrafinil vendor.

After extensive testing, we finally settled on three major options:

• Liquid: Science.Bio 

• Powders: Science.bio

• Capsules: Pure Rawz 

Science.bio is our favorite overall vendor. They produce superior quality Adrafinil liquid and powders. However, we recommend Pure Rawz for the highest quality Adrafinil capsules.

1. Science.bio

Science.bio is a well-known vendor of Adrafinil powder and other nootropic supplements. They pride themselves on providing high-quality products that are rigorously tested for purity and potency.

Here are some benefits of purchasing Adrafinil through Science.bio:

• Accurate dosing: Science.bio includes a 1mg scale with their Adrafinil powder to ensure accurate dosing. This is extremely important, as you risk serious side effects by using the incorrect dose.

• Fast shipping: Science.bio offers free shipping on all orders over $100, including of the fastest shipping rates for domestic and international orders.

• Extensive product testing: All of Science.bio’s products undergo extensive testing for quality control, purity, and potency. They also include a certificate of analysis for all of their products.

• Wide selection of supplements: In addition to Adrafinil, Science.bio offers a wide variety of other nootropics and research chemicals..

• Responsive customer service: Science.bio has some of the best and most helpful customer support in the business. No matter what your question is, their helpful staff is there to help!

Overall, Science.bio is the clear #1 choice for anyone looking for a high-quality online Adrafinil vendor.

If you’re ready to place your first order with Science.bio, here is where you can learn more.

2. Pure Rawz

Pure Rawz is another extremely high quality online Adrafinil vendor. They offer a wide variety of products, including nootropics and other research chemicals.

Just like Science.bio, they pride themselves in manufacturing some of the highest quality products that money can buy.

They are also our #1 recommendation for anyone looking to purchase Adrafinil capsules online.

Benefits of Pure Rawz include:

• Independent 3rd party testing performed on all of their products

• Incredibly fast shipping and superior customer service

• One of the most trusted names in nootropics and research chemicals

In summary, Pure Rawz is another excellent option for those looking for affordable Adrafinil capsules and other products.

Here is where you can learn more.

Adrafinil vs. Modafinil

Adrafinil and Modafinil are two popular nootropic compounds that are known for their ability to enhance cognitive function and promote wakefulness.

Here are some of the key differences between Adrafinil and Modafinil:

• Source: Adrafinil is a prodrug that is metabolized directly into Modafinil in the liver. On the other hand, Modafinil is not a prodrug and is directly used by the body.

• Legality: Adrafinil is legal to purchase without a prescription in the United States and most western countries. On the other hand, Modafinil use normally requires a valid doctor’s prescription - including in the US.

• Potency: Modafinil is somewhat more potent than Adrafinil, and requires lower overall doses to achieve the desired effects.

• Onset: Modafinil has a faster onset of action than Adrafinil, making it a better option for users desiring immediate results.

• Side Effects: Adrafinil is somewhat more likely to cause negative side effects such as headaches and stomach discomfort, while Modafinil is generally well-tolerated by most users.

Overall, Adrafinil and Modafinil have many similarities, but they also have distinct differences that potential users must be aware of.

Perhaps most importantly, Adrafinil is legal to purchase in the US and other countries without a prescription, while Modafinil often requires a legit doctor’s prescription.

Adrafinil vs. Fladrafinil

Adrafinil and Fladrafinil are two popular nootropic compounds that are often compared due to their similar effects. Here’s a closer look at the differences between Adrafinil and Fladrafinil:

Adrafinil

Adrafinil is a prodrug of Modafinil, meaning that it is metabolized in the body to produce Modafinil. It is known for its wakefulness-promoting effects and is often used as a cognitive enhancer. Here are some key differences and benefits of Adrafinil:

• Takes longer to take effect: Adrafinil takes longer to metabolize in the body compared to Fladrafinil, taking an hour or more to take effect.

• Lower potency: Adrafinil is less potent than Fladrafinil, meaning that higher doses may be required to achieve the same effects.

• Reduced risk of side effects: Thanks to its reduced overall potency, the risk of side effects with Adrafinil is considerably lower.

Fladrafinil

Fladrafinil is a derivative of Adrafinil and has been shown to be more potent and have a quicker onset of action. Here are some key differences and benefits of Fladrafinil:

• More potent: Fladrafinil is more potent than Adrafinil, and lower doses can be used to achieve similar effects.

• Fast-acting: Fladrafinil has a quicker onset of action compared to Adrafinil, typically taking effect within 20-30 minutes.

• Higher risk of side effects: Due to its potency, Fladrafinil may carry a higher risk of side effects such as insomnia, anxiety, and agitation.

Adrafinil and Fladrafinil are both powerful nootropic compounds that can be used to promote wakefulness and cognitive function.

Adrafinil is less potent and takes longer to take effect, but may be a safer option for those concerned about liver health. Fladrafinil is more potent and has a quicker onset of action, but may carry a higher risk of side effects.

Adrafinil vs. Hydrafinil

Adrafinil and Hydrafinil are two wakefulness-promoting drugs that have some similarities, but also have key differences.

Here are some of the differences between the two:

• Chemical structure: Adrafinil is a prodrug that is converted to Modafinil in the liver, while Hydrafinil has a distinct chemical structure.

• Potency: Hydrafinil is generally considered to be more potent than Adrafinil, and requires a lower dose to achieve similar outcomes.

• Duration of effects: Adrafinil has a longer half-life than Hydrafinil, which means its effects may last longer. However, Hydrafinil is absorbed more quickly into the body, which can lead to a faster onset of effects.

• Mechanism of action: Adrafinil is thought to work primarily by increasing levels of dopamine and norepinephrine in the brain, while Hydrafinil works by increasing levels of histamine and hypocretin.

• Availability: Adrafinil is not approved for medical use in most countries, while Hydrafinil is a more experimental drug that has not yet been clinically tested in humans.

Overall, both Adrafinil and Hydrafinil are wakefulness-promoting drugs that can improve cognitive function and promote alertness.

However, Adrafinil is generally considered to be a better overall choice for most users.

Adrafinil Stacks | What Combinations Work?

Adrafinil is often used in combination with other supplements for even greater benefits for mood and cognitive performance.

Here are some of the most popular Adrafinil stacks and the science behind them.

• Adrafinil + Caffeine: Caffeine is a well-known stimulant that increases alertness and cognitive function. When combined with Adrafinil, caffeine can prolong the wakefulness-promoting effects of Adrafinil.

• Adrafinil + L-Theanine: L-Theanine is an amino acid that is commonly found in green tea. It has been shown to promote relaxation and reduce anxiety. When combined with Adrafinil, L-Theanine can counteract the potential side effects of anxiety and jitteriness associated with Adrafinil use.

• Adrafinil + Phenibut: Phenibut is a GABA analog best known for its anxiolytic effects. When combined with Adrafinil, Phenibut can enhance the wakefulness-promoting effects of Adrafinil while promoting relaxation and reducing anxiety.

• Adrafinil + Piracetam: Piracetam is a nootropic compound that has been shown to improve cognitive function and memory. When combined with Adrafinil, Piracetam can enhance the cognitive-enhancing effects of Adrafinil.

• Adrafinil + Noopept: Noopept is a nootropic peptide that has been shown to enhance memory and cognitive function. When combined with Adrafinil, Noopept can enhance the cognitive-enhancing effects of Adrafinil.

In summary, Adrafinil can be stacked with a variety of supplements and nootropics to enhance its effects and promote cognitive function. Of course, users are encouraged to test Adrafinil on its own before “stacking” it with other compounds.

Is Adrafinil Legal?

Adrafinil is 100% legal to purchase and use in the United States and most western countries. This makes it an excellent alternative to Modafinil and other nootropics, which typically require a doctor’s prescription.

Here is the legal status of Adrafinil in various English-speaking countries:

• United States: It is 100% legal to purchase and possess Adrafinil in the United States without a prescription.

• Canada: Adrafinil is not regulated by Health Canada and is legal to possess and use.

• United Kingdom: Adrafinil is not a controlled substance in the UK, and is legal to possess and use for personal use.

• Australia: Adrafinil is not listed as a controlled substance in Australia, and can be legally purchased and possessed for personal use.

If you do not live in one of these countries, we encourage you to verify the legal status of Adrafinil for your legal jurisdiction. However, as a general rule of thumb, Adrafinil is generally legal in most countries around the world.

Adrafinil | Review of Uses, Dosage, and Side Effects

Adrafinil is a prodrug of modafinil with a similar chemical structure. Because of this, it may offer some brain-enhancing benefits — like increased focus and concentration, lasting energy and better memory.

However, how it affects the individual depends on their unique body chemistry — some subjects have reported that it worked great for them, while others have reported minimal effects.

If you plan to purchase adrafinil for research, the best place to buy it from is Science.bio because of their strict quality control practices and commitment to great service.

In many countries — the US, the UK and Canada included — adrafinil is not a prescription drug.

We like adrafinil because it provides nootropic benefits, but isn’t a prescription drug and can be ordered online for research purposes.

References

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2. U.S. National Library of Medicine. Modafinil. MedlinePlus website. February 15, 2016. https://medlineplus.gov/druginfo/meds/a602016.html

3. Siwak CT, Callahan H, Milgram NW. Adrafinil: effects on behavior and cognition in aged canines. Prog Neuropsychopharmacol Biol Psychiatry. 2000;24(5):709-726. doi:10.1016/s0278-5846(00)00103-2

4. Siwak CT, Gruet P, Woehrlé F, Muggenburg BA, Murphey HL, Milgram NW. Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs. Am J Vet Res. 2000;61(11):1410-1414. doi:10.2460/ajvr.2000.61.1410

5. Billiard M, Broughton R. Modafinil: its discovery, the early European and North American experience in the treatment of narcolepsy and idiopathic hypersomnia, and its subsequent use in other medical conditions. Sleep Med. 2018;49:69-72. doi:10.1016/j.sleep.2018.05.027

6. Milhaud CL, Klein MJ. Effets de l’adrafinil sur l’activité nocturne du macaque rhésus (Macaca mulatta) [The effect of adrafinil on the nocturnal activity of the rhesus monkey (Macaca mulatta)]. J Pharmacol. 1985;16(4):372-380.

7. Siwak CT, Gruet P, Woehrlé F, et al. Behavioral activating effects of adrafinil in aged canines. Pharmacol Biochem Behav. 2000;66(2):293-300. doi:10.1016/s0091-3057(00)00188-x

8. Milgram NW, Siwak CT, Gruet P, Atkinson P, Woehrlé F, Callahan H. Oral administration of adrafinil improves discrimination learning in aged beagle dogs. Pharmacol Biochem Behav. 2000;66(2):301-305. doi:10.1016/s0091-3057(00)00175-1

9. N = de Belleroche J, Cook GE, Das I, et al. Erythrocyte choline concentrations and cluster headache. Br Med J (Clin Res Ed). 1984;288(6413):268-270. doi:10.1136/bmj.288.6413.268