Unable to handle Wake Forest's quickness and athleticism, BYU remained winless on the road against ACC opponents as the Demon Deacons routed the Cougars 79-62 at Joel Coliseum.
The Cougars (11-4) were able to hang with North Carolina earlier in the season in Las Vegas, but they were no match for a youthful Wake Forest team on its home court.
BYU was overwhelmed in nearly every statistical category in suffering its worst loss of the season and dropping to 0-8 all-time against ACC opponents on the road.
BYU shot just 35.9 percent (23 of 64) and turned the ball over 22 times. Wake Forest outscored BYU 34-20 in the paint.
Lee Cummard led BYU with 15 points, but needed 17 shots to get there. Trent Plaisted was just 3 of 10 from the field and finished with eight points - his first game not to reach double figures this season - and Jonathan Tavernari shot just 2 for 11 for nine points.
Using its speed to continually drive around BYU defenders, Wake Forest (11-3) shot a sizzling 51.7 percent in scoring the most points against BYU this season.
Jeff Teague led four Wake Forest players in double figures scoring with 26 points while James Johnson added 19.
The Cougars will fly home tomorrow and open Mountain West Conference play on Saturday against Colorado State at the Marriott Center.