DETROIT - Kyle Orton set career highs in yards passing, completions and quarterback rating while throwing two touchdowns. He was 24-for-34 for 334 yards and had a 121.4 rating, improving to 3-0 against the Lions. Chicago built a 31-0 lead before rookie Kevin Smith scored for the Lions midway through the third quarter.

Falcons 27, Packers 24

GREEN BAY, Wis. - Atlanta rookie quarterback Matt Ryan turned in another sharp performance, completing 16 of 26 passes for 194 yards, two touchdowns and an interception.

Falcons receiver Roddy White caught eight passes for 132 yards and a touchdown, and Michael Turner ran for 121 yards and a touchdown.

Aaron Rodgers started for the Packers despite a sprained shoulder that kept him out of practice for most of the week. He got better as the game went on, even as the signs that his shoulder was bothering him became more obvious.

Panthers 34, Chiefs 0

CHARLOTTE, N.C. - DeAngelo Williams rushed for 123 yards and scored three touchdowns and the Panthers handed the Chiefs their first shutout in nearly six years.

Williams and Jonathan Stewart ran through a woeful defense that also couldn't stop the pass. Steve Smith caught six passes for 96 yards, and Muhsin Muhammad had a 47-yard touchdown catch.

Titans 13, Ravens 10

BALTIMORE - The Titans are still unbeaten thanks to a late touchdown drive and a defense that outperformed the top-ranked unit in the league.

Kerry Collins threw an 11-yard touchdown pass to Alge Crumpler with 1:56 left. The Titans trailed 10-6 before Collins directed an 11-play, 80-yard scoring drive. Baltimore rookie Joe Flacco was then intercepted by Nick Harper, assuring the Ravens a second straight defeat.

Giants 44, Seahawks 6

EAST RUTHERFORD, N.J. - In a nearly flawless performance, Eli Manning threw two touchdowns, Brandon Jacobs ran for two more and the unbeaten Giants scored on their first five possessions. Not only did the Giants win, but they also did so with leading receiver Plaxico Burress suspended for a game.

Cardinals 41, Bills 17

GLENDALE, Ariz. - Quarterback Trent Edwards, a major reason Buffalo was one of three unbeaten teams entering the day, went down with a concussion on a fierce hit from safety Adrian Wilson on the third play of the game. It was the Bills' defense that collapsed after that.

Rookie Tim Hightower scored on a pair of touchdown runs, and Kurt Warner threw to Larry Fitzgerald twice for scores.

J.P. Losman, who wanted an offseason trade after losing his job to Edwards, was 15-for-21 for 220 yards.

Patriots 30, 49ers 21

SAN FRANCISCO - From Randy Moss' dynamic 66-yard touchdown catch to Kevin Faulk's score on a direct snap, the Patriots returned to their usual regular-season form. Faulk rushed for two scores, Matt Cassel had 259 yards passing and the Patriots won in San Francisco for the first time in franchise history.

Redskins 23, Eagles 17

PHILADELPHIA - Clinton Portis ran for 145 yards and one touchdown and receiver Antwaan Randle El threw a TD pass for Washington, which won another big NFC East game on the road.

Shaun Suisham kicked three field goals beyond 40 yards, helping the Redskins overcome a 14-0 deficit. Jason Campbell threw for 176 yards and Washington's offense didn't commit a turnover for the fifth straight game.

DeSean Jackson had a 68-yard punt return for a score, but the Eagles couldn't generate much on offense. Brian Westbrook, back after missing a game with an ankle injury, amassed just 84 total yards.