Hawaii Gov. Neil Abercrombie said the state is prepared for the back-to-back storms, noting the National Guard is at the ready and state and local governments were closing offices, schools and transit services across Hawaii. Emergency shelters also are being opened across the state.
Meanwhile, state Attorney General David Louie promised that Saturday's primary elections will go forward as planned.
Earlier Thursday, a 4.5-magnitude earthquake struck the Big Island but didn't cause major damage. There were no reports of injuries as residents made last-minute trips to grocery stores and boarded up their homes.
Kelsey Walker said the quake felt like a "little jolt" but didn't knock things off shelves at the Waimea grocery store where he works. He was trying to keep a sense of humor about it.
"We have a hurricane. Now we have this on top of it. What else?" Walker mused.
Travelers got their first word of disrupted plans Thursday, when commuter airline Island Air said it was canceling some afternoon flights between the islands and shutting down all operations Friday.
Hurricane Iselle was expected to bring heavy rains, winds gusting up to 85 mph and flooding in some areas, but officials said the Big Island's mountainous region and size should help break apart and weaken the storm as it passed on to Maui and Oahu late Thursday and early Friday.
"Not a major hurricane, but definitely enough to blow things around," said meteorologist Mike Cantin of the National Weather Service.
Hawaii has been directly hit by hurricanes only three times since 1950, though the region has had 147 tropical storms over that time. The last time Hawaii was hit with a hurricane was in 1992, when Iniki killed six people and destroyed more than 1,400 homes in Kauai, meteorologist Eric Lau said.
The twin hurricanes have disrupted tourism, prompted flash flood warnings and led to school closures.
Hawaiian Airlines waived reservation change fees and fare differences for passengers who needed to alter their plans Thursday and Friday, while some travelers remained optimistic.
Boston resident Jonathan Yorke and his wife booked a Hawaii vacation with their two daughters last year. He has been watching the news to see how the storms could affect their two-week trip to Maui and the Big Island.
"We're all optimists, so we'll make the best of it," Yorke said.
Washington state couple Tracy Black and Chris Kreifels made plans to get married in an outdoor ceremony on the Big Island on Saturday. They spent this week getting a marriage license, adjusting plans and communicating with worried guests on the mainland.
"We see the rain as a blessing," Black said. "It will work out as it's supposed to."
Some residents, meanwhile, are voting early in the primary elections that include congressional and gubernatorial races.