This month marks the 35th anniversary of the Sandinistas' ouster of dictator Anastasio Somoza, and as always on such occasions, Murillo stood beside Ortega at the official commemoration, welcoming Latin American dignitaries with a bejeweled fist raised in triumph.
"The faith in each and every one of us has made it possible for God to fill us with miracles," Murillo told the crowd.
"Who would have said that 35 years would pass so quickly, always in the scent and roar of combat," she went on. "The revolutionary people of centuries past and present inspire us in the advance of socialism that, for us in Nicaragua, is made up of Christian faith, family values, the life and spirit of community."
Politics long have been a family affair in Nicaragua, and Latin America has a tradition of women leaders stepping in when their husbands leave the political stage. Given that, the political partnership of Ortega and Murillo leads many here to speculate that she aspires to succeed Ortega as president one day.
Ortega may have fueled a recent spate of such talk in April after a magnitude 6.2 earthquake damaged many buildings in the capital of Managua. He went on television to say that while he protected their grandchildren, Murillo began issuing instructions to Cabinet members.
"The problem with the presidential couple is that their vocation is to remain in power," said Rosa Maria Zelaya, former president of the council overseeing elections. "They are preparing the succession in the person of Murillo, for whenever it is necessary."
Barring illness or death, the 67-year-old Ortega is not likely to leave office soon, thanks to his backers in Congress and on the Supreme Court who approved a constitutional change allowing for unlimited re-election. And supporters say the image of a power-hungry first lady is a form of sexism that overlooks her many contributions to Nicaragua.
"The opposition would love for Murillo not to exist," said Aldo Diaz Lacayo, former Nicaraguan ambassador to the United Nations. "She is efficient, productive and pivotal in implementing all of the government policies."
Murillo, 63, joined the Sandinista movement in the 1960s, while working as a secretary to La Prensa newspaper editor Pedro Joaquin Chamorro, who was later assassinated for his opposition to the Somoza regime.
In a photograph taken July 19, 1979, the day Somoza fled Nicaragua, Murillo is wearing green fatigues, a black beret over short hair, and a rifle slung over her shoulder, standing with several of the nine Sandinista commandants who led the uprising.
Today, Murillo's shoulders are draped in her jet black hair and colorful outfits, many of them pink and blue, apparently for the New Age colors of divine purpose and harmony with family and the world. Besides references to God, Murillo's speeches are peppered with allusions to the mysteries and miracles of life, and Mother Earth.
Many Nicaraguans see her as their protector.
"We are the children and she is the mother who takes care of us," said Dennis Centeno, a computer programmer who was attending a concert in commemoration of the Sandinistas' namesake, Augusto Cesar Sandino.
A lover of jewelry, Murillo wears multiple necklaces and bracelets and several turquoise rings on each finger. Her style provides a vibrant contrast to Ortega, who has grown bald and paunchy with age, and usually dresses in a plain white shirt.