Indianapolis • Andrew Luck and the Colts ruined Peyton Manning's return to Indianapolis and handed the Denver Broncos their first loss of the season.
Luck, who replaced Manning as quarterback of the Colts, threw for 228 yards and three touchdowns, ran for another score and didn't even need a fourth-quarter comeback to end Denver's 17-game regular-season streak with a 39-33 victory Sunday night.
While Luck was terrific in prime time, completing 21 of 38 passes, his predecessor was not himself. Manning finished 29 of 49 for 386 yards with three TDs, one interception and was sacked four times, leaving the Kansas City Chiefs as the NFL's only unbeaten team.
Passes sailed high, passes fluttered and the man who usually escapes trouble with his quick thinking and quick release was sacked twice and lost a fumble near the goal line. Robert Mathis, one of the few holdovers from the Manning Era, got one of his trademark strip sacks in the second quarter a mistake that led to nine points for Indianapolis (5-2).
The offense that was on a record scoring pace and seemed virtually unstoppable over the first six weeks managed only two first-half touchdowns and opened the third quarter with three straight three-and-outs.
Kick returner Trindon Holliday twice fumbled the ball, with one leading to an Indianapolis touchdown, and the defense of the Broncos (6-1) that spent nearly three-fourths of the season playing with the lead came unglued in the third quarter with penalty after penalty aiding Colts drives.