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Buenos Aires, Argentina • Madrid has been eliminated as a host city for the 2020 Olympics, leaving Tokyo and Istanbul to advance to the final round.

Madrid initially tied with Istanbul as an also-ran in the voting by the International Olympic Committee. Istanbul won the tiebreak vote 49-45.

The winner will now be determined in a second-round vote between the Japanese and Turkish cities. Leading Tokyo's final pitch for the 2020 Olympics, Japan's prime minister assured the IOC on Saturday that the leak of radioactive water from the Fukushima nuclear plant is "under control" and will never affect Tokyo.

Tokyo has been considered a slight favorite but has been on the defensive in the final days of the campaign amid mounting concerns about the Fukushima leak.

"Some may have concerns about Fukushima," Prime Minister Shinzo Abe said in English. "Let me assure you the situation is under control. It has never done and will never do any damage to Tokyo."

Abe returned to the issue later when Norwegian IOC member Gerhard Heiberg asked for more assurances.

"It poses no problem whatsoever," Abe said in Japanese, adding that the contamination was limited to a small area and had been "completely blocked."

"There are no health related problems until now, nor will there be in the future," he said. "I make the statement to you in the most emphatic and unequivocal way."

Tokyo Electric Power Co., Fukushima's operator, has acknowledged that tons of radioactive water has been seeping into the Pacific from the plant for more than two years after the March 2011 earthquake and tsunami led to meltdowns at three of its reactors. Recent leaks from tanks storing radioactive water used to cool the reactors have added to fears that the amount of contaminated water is getting out of hand.

With major risks surrounding each bid, the final presentations could help decide a tight race. Abe and Prime Ministers Recep Tayyip Erdogan of Turkey and Mariano Rajoy of Spain all flew to Buenos Aires straight from the G20 summit in St. Petersburg, Russia.

All three are repeat bidders: Istanbul for a fifth time overall, Madrid for a third straight and Tokyo a second in a row. Picking the city with the least risks shapes up as the challenge for the IOC.

Tokyo continued to portray itself as the safe choice at a time of global political and economic uncertainty.

"Tokyo can be trusted to be the safe pair of hands and much more," bid leader and IOC member Tsunekazu Takeda said. "Our case today is simple. Vote for Tokyo and you vote for guaranteed delivery. ... Tokyo is the right partner at the right time."

Tokyo's delegation also included Japan's Princess Takamado.

"This may be the first time a member our family has addressed you, but the imperial family of Japan has always been active in sports," she said.

Istanbul, making its fifth overall bid, was up first. The Turkish delegation pressed its case to take the Olympics for the first time to a predominantly Muslim country, to a city linking the continents of Europe and Asia.

With the civil war in neighboring Syria posing a major issue for the Istanbul bid, Erdogan said taking the games to Turkey "will send a very meaningful and strong message, not only to the world, but to our broader region."

"At this critical moment, we would like to send a strong message of peace to the whole world from Istanbul," Erdogan said.

After the formal presentation, IOC member Prince Albert of Monaco asked what hosting the games in Turkey would mean to the wider region.

"We believe that hosting the Olympics in Istanbul will give this signal, this spirit of friendship and sharing and peace," Erdogan said. "And our country is a place where there is a lot of unity and diversity, and that is the idea that we can share on a broader scale with the Olympics Games being hosted in Turkey."

Istanbul's bid has also been hit hard by the anti-government protests in June and a slew of doping scandals among Turkish athletes.

Turkish IOC member Ugur Erdener promised that Turkey "will continue to enforce our zero-tolerance policy on doping." Sports Minister Suat Kilic said Turkey would use criminal laws to prosecute anyone involved in promoting the use of banned substances.

"We understand that there is no gain without pain," Erdener said in response to a question. "Now we have a very organized anti-doping organization."

Deputy Prime Minister Ali Babacan talked up Turkey's growing economy and insisted that Istanbul's high construction budget was "financially responsible" and the money already being invested.

Madrid, once counted out because of Spain's financial troubles, has generated the most recent buzz and momentum, and could be poised for an upset win.

London bookmakers have been taking a rush of bets on Madrid, whose odds have been slashed from 4-1 a week ago to 5-4. Tokyo remains the betting favorite, though its odds have shortened to 5-6. Istanbul is listed at 6-1.

IOC elections are extremely unpredictable as members vote by secret ballot and take different personal reasons into account. Some members are still undecided and will be waiting for the final presentations before making up their mind.

With two IOC members absent, 95 will be eligible to vote in the first round. With a majority required for victory, the process is likely to go two rounds. The city with the fewest votes is eliminated after the first round, setting up a final head-to-head ballot. Outgoing IOC President Jacques Rogge will open a sealed envelope to announce the winner.