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Philadelphia • Let upsets take down other heavy favorites. Duke is back to business as usual.

Rasheed Sulaimon scored 21 points, Seth Curry scored had 17 and No. 2 seed Duke held off seventh-seeded Creighton 66-50 on Sunday to advance to the round of 16 for the fourth time in five years.

A year after they lost their NCAA tournament opener, the Blue Devils (29-5) are back in the regional semifinal for the 23rd time. They'll play No. 3 seed Michigan State (27-8) in the regional semifinal Friday in Indianapolis.

Mason Plumlee, Josh Hariston and Ryan Kelly battled foul trouble all game long that could have doomeed the Blue Devils. Creighton (28-8) went cold and never made a serious run in the second half. Doug McDermott scored 21 points but made only four baskets.

With McDermott slumping, the Bluejays were knocked out in the third round by an ACC team for the second straight season.

Florida Gulf Coast beat San Diego State 81-71 in the opener in Philadelphia that had the crowd of more than 20,000 buzzing after the upset win.

Duke's win could not match it in excitement and intensity.

But that's OK for the Blue Devils. They're not in it for style points. They're here to win coach Mike Krzyzewski's fifth national championship.

Still, the Blue Devils haven't advanced past the round of 16 since Krzyzewksi won his fourth national championship in 2010. They lost last year to Lehigh and spent their first three days in Philadelphia still having to answer for that one. Yes, even after they beat Albany in the second round.

Foul trouble hounded the Blue Devils from the opening tip. Plumlee hit the bench after he was whistled for his fourth foul early in the second half.

Hariston picked up his fourth foul at the 15:21 mark, allowing Ethan Wragge to convert a three-point play that inched the Bluejays closer.

Curry came right back with a 3 and followed with a layup to make it 39-30. Plumlee and Kelly, each with four fouls, returned to the game as Krzyzewksi clearly wanted his best players in there to try and put away the Bluejays.

The usually sure-shooting Creighton never found its groove.

Gregory Echenique had no chance on a wayward alley-oop lob that knocked off the backboard and he fumbled the ball the next time down. Amile Jefferson scored off the second turnover for an 11-point lead. Hundreds of Duke fans stood in appreciation and the win was all but in the bag.

Hariston got his fifth foul at the midway point leaving the Blue Devils without a key frontcourt reserve. Plumlee fouled out with just under 3 minutes left.

But the Bluejays clanged brick after brick. The missed 17 of 19 3-pointers and shot only 30 percent from the field. McDermott, their All-American, was 4 of 16 and 12 of 12 from the free-throw line.

McDermott gamely did his best to keep the Bluejays afloat by getting to the free throw line. He hit two with 7:29 left to cut it to nine but went more than 18 minutes without a field goal. Without his 3-point shooting keeping Duke's defense honest — Krzyzewksi called him one of the best offensive players he's seen in the last decade — the Bluejays were sunk.

Curry's second 3-pointer pushed it back to 11 and Suilman followed with another 3 to wrap it up.

Plumlee finished with 10 points and the Blue Devils made 21 of 28 free throws.

Tyler Thornton banked a running 3 at the buzzer to send Duke into halftime with a 29-23 lead. The Bluejays missed 12 of their first 15 shots of the game, then missed 10 of 13 to open the second half. They lost in the third round to North Carolina a year and talked all year about wanting to get back to this point. They would go no farther. The Bluejays haven't advanced to a regional semifinal since the tournament expanded to 64 teams in 1985 Krzyzewksi again celebrated a big win in Philadelphia, though with far less drama. The Blue Devils topped Kentucky in the 1992 East Region final on Christian Laettner's buzzer-beater in perhaps the greatest game and shot in the tournament's 75-year history.

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