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Paris • Serena Williams lost in the first round of a major tournament for the first time in her career, falling to Virginie Razzano of France 4-6, 7-6 (5), 6-3 Tuesday at the French Open.

The fifth-seeded Williams was two points from victory several times in the second set, including leading 5-1 in the tiebreaker. But Razzano won six straight points to force a third set, and then took control of the match.

"I made so many errors today, which isn't the game I was playing in the past," Williams said. "That's life."

Williams entered the day with a 46-0 record in first-round matches at Grand Slam tournaments. She had been looking for her 14th major title, and second at Roland Garros.

The 13-time Grand Slam champion had five break points in the final game, but she couldn't convert.

"I was just thinking, if I can break here we'll be back on serve," Williams said.

Razzano saved all five, and then converted her eighth match point to eliminate one of the tournament favorites.

"I had to dig deep against a great champion and you could see until the end that she gave away nothing," Razzano said. "I had to go and get the victory. I had to be mentally strong, and I gave my everything."

Earlier, Rafael Nadal began his quest for a record seventh French Open title in style, wearing a pink shirt and pink shoelaces.

He won easily, too.

The second-seeded Spaniard had little trouble against Simone Bolelli of Italy, winning 6-2, 6-2, 6-1 on Court Philippe Chatrier — the same stadium where Nadal has won six of his 10 Grand Slam titles.

Nadal, who is tied with Bjorn Borg with six French Open titles, improved his record to 46-1 at Roland Garros. His only loss came in the fourth round in 2009, against Robin Soderling.

He's not worried about the record just yet, though.

"We are in the second round," Nadal said. "I have enough work to do thinking about the next round, and not think about if Bjorn will be here or if I'm going to play the final. That's day-by-day and we'll see."

Against Bolelli, Nadal made only 18 unforced errors, fewer than half as many as his opponent. From 2-2 in the first set, Nadal won eight straight games to take control.

"I think I did what I had to do today," Nadal said. "I played probably with less stress or nerves than in other first rounds in the past."

Fourth-seeded Andy Murray also advanced, beating Tatsuma Ito of Japan 6-1, 7-5, 6-0.

Maria Sharapova was nearly perfect in her match, winning all 12 games to produce a "double bagel." And Wimbledon champion Petra Kvitova advanced by beating junior Wimbledon champion Ashleigh Barty 6-1, 6-2.

Sharapova routed Alexandra Cadantu of Romania 6-0, 6-0 on Court Suzanne Lenglen, needing just 48 minutes to advance to the second round.