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(Rick Egan | The Salt Lake Tribune) Donald A. McClain, endocrinologist and a professor of internal medicine, Josef Prchal, a professor of internal medicine at the U. School of Medicine, and Tsewang Tashi, a Tibetan who is a hematologist and researcher at the Huntsman Cancer Institute, in Prchal's lab at the University of Utah Medical Center, Friday, August 15, 2014. University of Utah scientists are the lead researchers on a study publishing Sunday in the journal Nature Genetics. The study concludes that Tibetans who thrive in the thin air of the Tibetan Plateau (average elevation 14,800) do so because of a genetic mutation 8,000 years ago.
8,000-year-old genetic mystery in Tibet solved by Utah study
Genetics » A mutation 8,000 years ago made them fit for heights.
First Published Aug 17 2014 11:15 am • Last Updated Aug 29 2014 09:18 am

Thriving at high altitude, where most mortals suffer from oxygen deprivation? There’s a gene for that.

A study led by University of Utah researchers has identified for the first time the genetic reason Tibetans can live without medical complications on the Tibetan Plateau, which has an average elevation of 14,800 feet.

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The results of the study, led by senior author Josef Prchal, an internist and hematologist at the U., were published online Sunday in the journal Nature Genetics.

By taking blood samples from 26 Tibetans living in Utah and Virginia — as well as dozens more from Tibetans and other Asians living in China and India — they found the gene EGLN1 changed by a single DNA base pair.

Lowlanders who lack the genetic mutation suffer in thin air because their blood becomes thick with oxygen-carrying red blood cells in an attempt to feed oxygen-starved tissues. That can lead to long-term complications such as acute mountain sickness or heart failure, Prchal said.

But Tibetans’ bodies do not react to high altitude by producing extra red blood vessels.

The mutation apparently began 8,000 years ago and "spread like fire" through the population, he said. Those who had it thrived and, by natural selection, their offspring did, too.

Today, 88 percent of Tibetans have the genetic variation, but it is virtually absent in closely related lowland Asians, the study found.

DNA from Chinese, Japanese, Koreans, Mongolians and Filipinos were compared against the Tibetan DNA.

"The significance is … that we understand more about evolution," said Tsewang Tashi, a research associate at the university’s Huntsman Cancer Institute and one of the study’s authors.


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Tashi, who was born in India to Tibetan parents, came to the U. in 2012 and was a great help during visits to Asia, Prchal said.

Prchal began the research in 2007, but it was complicated by cultural and political difficulties.

A partnership between Qinghai province in the north of China and the university, formalized when former Utah Gov. Jon Huntsman was ambassador to China, laid some groundwork. Prchal was able to do research at the Research Center for High-Altitude Medicine of Qinghai University and initial results were published in 2010.

Prchal also was able to meet with the Dalai Lama in Prague, Czech Republic, and the Tibetan people’s spiritual leader wrote a letter endorsing the research.

Prchal and the Dalai Lama had a mutual friend — now-deceased Czech Republic President Vaclav Havel — and that helped, said Prchal, who fled communist Czechoslovakia in 1968.

Tashi knew the culture and language and could help Tibetans understand the research, Prchal said. Tashi also recruited Tibetans living in Utah and Virginia to donate their blood for DNA testing.

Pema Chagzoetsang, who was just 10 months old when her parents fled Tibet over the Himalayas in 1959 to escape the communist regime in China, was one of those donating her blood for the study. A program specialist for the state homeless program, she also recruited other Tibetans living in Salt Lake City.

Chagzoetsang draws a political implication from the research. "We are all saying we are not Chinese, and this proves it," she says.

Prchal is thinking more along medical lines. "This mutation is extremely important because it regulates many functions in the human body," he said.

It might have implications for cancer research, and also for diabetes or high blood pressure at low elevations. One of the study’s authors, U. endocrinologist Donald McClain, for instance, continues to research a connection to obesity and diabetes.

"There’s much more to be learned," Prchal said.

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