In early European trading, France's CAC 40 fell 0.4 percent to 4,524.90 while Germany's DAX shed 0.3 percent to 9,885.46. The FTSE 100 index of leading British companies slipped 0.1 percent to 6,768.64.
U.S. stocks were poised to open lower, with Dow futures down 0.2 percent to 16,669.00. S&P 500 futures dipped 0.2 percent to 1,924.20.
Investors were also readying for the regular meeting of the Federal Reserve Board's policy setting Open Market Committee, scheduled for midweek. While policymakers are widely expected to announce that the Fed will cut its bond-purchase program by another $10 billion, investors will be examining their comments on the outlook for raising interest rates, economic growth and inflation.
"The FOMC statement in the early hours of Thursday morning is undoubtedly the primary focus for all global markets this week," said Niall King, a sales trader at CMC Markets in Sydney.
In Asia, most benchmarks were lackluster but stocks in the region's two biggest economies moved strongly — in opposite directions.
Japan's benchmark Nikkei 225 sank 1.1 percent to close at 14,933.29 as the yen strengthened 0.1 percent to 101.93 against the dollar. A stronger yen means the cars and electronics produced by Japan's export giants are more costly when sold overseas.
In mainland China, the Shanghai Composite Index rose 0.7 percent to end at 2,085.98 after Chinese Premier Li Keqiang, writing in The Times newspaper ahead of a visit to Britain, said that he expects the world's No. 2 economy to grow "around 7.5 percent this year," in line with the government's target.
Hinting that the government is prepared to roll out more mini-stimulus measures, Li said, "Despite considerable downward pressure, China's economy is moving on a steady course. We will continue to make anticipatory and moderate adjustments when necessary."
South Korea's Kospi edged 0.1 percent higher to 1,993.59 while Hong Kong's Hang Seng slipped less than 0.1 percent to 23,300.67. Australia's S&P/ASX 200 was rose 0.1 percent to 5,412.30.
Taiwan, Singapore and New Zealand benchmarks edged higher while Indonesia and the Philippines drifted lower.
In energy trading, benchmark crude oil for July delivery rose 35 cents to $107.26 in electronic trading on the New York Mercantile Exchange. The contract rose 38 cents to close at $106.91 on Friday.
The euro fell to $1.3527 from $1.3540.