Jared Leto presented Mila Kunis with the award for best villain for "Oz the Great and Powerful," "You just made my 12-year-old self dream come true," said Kunis while holding her golden popcorn prize. "And I just realized I'm the only woman nominated and I won."
Accepting the popcorn-shaped prize from Jessica Alba and Rita Ora for best shirtless performance for "That Awkward Moment," Zac Efron hesitated to take his shirt off on stage until Ora ripped it open. He then finished the job and took it off.
Receiving this year's trailblazer award was Channing Tatum. The first male to gain the honor after Emma Stone and Emma Watson, Tatum accepted the award from his "Jupiter Ascending" co-star Kunis and his "22 Jump Street" co-star Jonah Hill. Tatum admitted he thought he was being punked when he found out he would get the award.
Host Conan O'Brien kicked off the 22nd annual ceremony with a challenge to gain 50 celebrity cameos for his opening segment, a shtick with Will Arnett that merged two categories — best fight and best kiss — and a musical number about hating musical numbers in big awards shows.
Walking out to a track by rapper Rick Ross, O'Brien joked that he was almost injured by the show's flashing pyrotechnics. "Fire, explosions and rap music: all things you associate with Conan O'Brien," he deadpanned.
Earlier in the evening, Amanda Seyfried had trouble reading the teleprompter, blaming it on not wearing her contacts. "So far this is going about as well as the Oscars," said her co-presenter Seth MacFarlane — referencing his 2013 Academy Award hosting gig — before the pair presented Johan Hill with his award for best comedic performance for "The Wolf of Wall Street."
Hill's initial thanks went to all of his friends with whom he used to watch the show back home before making it to the ceremony himself.
In the preshow awards, the prize for best cameo performance went to Rihanna for her appearance in the comedy "This is the End."
During the show, Rihanna took to the stage with Eminem to perform their hit "The Monster."
Best kiss went to Emma Roberts, Jennifer Aniston and Will Poulter.
Movie of the year nominees included "12 Years a Slave," "The Hunger Games: Catching Fire," "The Hobbit: The Desolation of Smaug," "The Wolf of Wall Street" and "American Hustle."
The show was to also feature a special honor to Mark Wahlberg, and a special tribute was planned for Paul Walker, who died in a car crash last November.
The MTV awards had some stiff competition from other networks on Sunday night, including the latest installment of HBO's popular "Game of Thrones" and the final season premiere of AMC's "Mad Men."