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Geneva • A triple bombing killed at least 50 people Sunday in a predominantly Shiite suburb south of the Syrian capital of Damascus even as a U.N. mediator held his first meeting with members of the main opposition group that seeks progress on humanitarian issues before it will join formal talks on ending the five-year civil war.

The attacks were claimed by militants from the Islamic State, and Syria's delegate to the U.N.-sponsored peace talks said the violence confirmed the connection between "terrorism" and "some political groups" — a reference to those who oppose President Bashar Assad.

The blasts went off in the Damascus suburb of Sayyda Zeinab, about 600 yards from one of the holiest shrines for Shiite Muslims. Syria's state news agency SANA said the attackers detonated a car bomb at a bus stop and that two suicide bombers then set off more explosives as rescuers rushed to the area.

State TV showed several burning cars and a scorched bus, as well as blown-out windows, twisted metal and large holes in the facade of a nearby apartment building. The golden-domed Shiite shrine itself was not damaged.

At least 50 people were killed, the Syrian Foreign Ministry said, with more than 100 wounded.

The Syrian Observatory for Human Rights, a Britain-based opposition group that monitors the war, said at least 63 people were killed, including 25 pro-government Shiite fighters. It said the dead fighters included Syrians and foreigners.

The suburb is one of the first areas where Lebanon's Hezbollah group sent fighters in 2012 to protect it from Sunni extremists who vowed to blow up the shrine. Hezbollah and Shiite groups from Iraq are known to have fighters in the area.

A website affiliated with the Islamic State said the attacks were carried out by members of the Sunni Muslim extremist group, which controls large areas in both Syria and Iraq.

The bombings cast a shadow over the talks in Geneva, the first U.N. effort since 2014 to try to end the war that has killed at least 250,000 people, forced millions to flee the country and given an opening to Islamic State militants to capture territory.

In Washington, U.S. Secretary of State John Kerry appealed to both sides "to make the most of this moment, to seize the opportunity for serious negotiations, to negotiate in good faith with the goal of making concrete measurable progress in the days immediately ahead."

The talks got off to a rocky start Friday when U.N. special envoy Staffan de Mistura met only with a Syrian government delegation. The main opposition group, the Saudi-backed Higher Negotiations Committee (HNC), boycotted the session, saying it won't take part until preliminary demands are met: the release of detainees, the end of the bombardment of civilians by Russian and Syrian forces, and the lifting of government blockades on rebel-held areas.

On Sunday, de Mistura paid an informal visit to the HNC delegation, saying he is "optimistic and determined" about the talks.

HNC spokesman Salem al-Mislet told The Associated Press that the violence against civilians must stop first, saying the U.N. Security Council should put "pressure on Russia to stop these crimes in Syria," he said. Moscow, which began its airstrikes in Syria in September, is a major Assad ally, along with Iran.

But Bashar Ja'afari, the head of the Syrian delegation, criticized the opposition in remarks to reporters.

"Those who speak about preconditions are coming to this meeting in order to derail it," he said. "With the opposition's delegation not showing up, it shows that they are not serious and irresponsible at a time when Syrians are being killed."

Ja'afari added that the Damascus-area bombings "confirms what the Syrian government has stated before — that there is a link between terrorism and the sponsors of terrorism from one side, and some political groups, who claim that they are against terrorism."

Assad's government has long referred to all those fighting to overthrow him as terrorists, but has agreed to negotiations with some armed groups in the latest talks.