Studies find young blood rejuvenates aging mice
Published: May 4, 2014 08:31PM
Updated: May 4, 2014 08:31PM
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This combination of images provided by Lida Katsimpardi in May 2014 shows 3-D reconstructions of brain blood vessels in, from left, a young mouse, an old mouse, and an old mouse who was exposed to the blood of a young mouse. Older mice got stronger, exercised longer and performed better mentally after they were injected with blood from young mice, or even just with a substance that's more abundant in younger blood according to three papers published online Sunday, May 4, 2014 by the journals Science and Nature Medicine. (AP Photo/Lida Katsimpardi)

New York • If Mickey Mouse is feeling his age at 86, scientists may have found just the tonic: the blood of younger mice.

Older mice got stronger, exercised longer and performed better mentally after they were injected with blood from young mice, or even just with a substance that’s more abundant in younger blood.

Someday, if more research goes well, this may lead to a way to treat some infirmities of old age in humans. In the meantime, scientists have a warning for do-it-yourselfers.

“Don’t try this at home,” said Saul Villeda of the University of California, San Francisco, an author of one of three papers published online Sunday by the journals Nature Medicine and Science.

He worked with mice that were roughly the equivalent of people in their 20s and 60s. Researchers repeatedly injected the older mice with blood from either the younger animals or other aged mice. Those that got the young blood did better in learning and memory tests than the mice given the older blood.

The two other papers, from Harvard University, focused on a substance that is more abundant in the blood of younger mice than older. That protein, called GDF11, is also found in human blood and its concentration also appears to decline with age, said Amy Wagers, an author on both papers. On average, aging mice that got injections of it showed greater grip strength and more endurance on a treadmill than untreated mice. The Harvard scientists also found that exposing older mice to the blood of younger mice produced more blood vessels and blood flow in the brain. Injections of GDF11 had a similar effect.