Louisville, Ky. » Louisville gave Freedom Hall a memorable send-off.

Sophomore guard Kyle Kuric scored all of his career-high 22 points in the second half and the Cardinals upset No. 1 Syracuse 78-68 on Saturday, providing one last highlight at their 54-year-old home.

Louisville (20-11, 11-7 Big East) may also have assured itself a return trip to the NCAA tournament by sweeping the season series from the Orange (28-3, 15-3). Their only other loss all season came against Pittsburgh, and Saturday was their first road loss.

Although Syracuse led by eight points late in the first half, Kuric was a one-man wrecking crew in the second. He made 9 of 11 shots -- including four 3-pointers -- to make for a happy ending at Freedom Hall, before Louisville moves to a new downtown arena in the fall.

"It's the kind of game every kid dreams of," Kuric said. "I got my opportunity and just tried to make the most of it."

Scoop Jardine came off the bench to score a team-high 20 points for Syracuse.

Freedom Hall has hosted six national championship games, a handful of NCAA tournament regional finals and 683 Louisville victories.

No. 4 Duke 82, North Carolina 50 » Kyle Singler scored 19 of his 25 points in the first half and Duke routed North Carolina for its most lopsided home win over its fiercest rival.

Iowa State 85, No. 5 Kansas State 82, OT » In Manhattan, Kan., Diante Garrett scored five points in overtime and Iowa State stunned the Wildcats to snap a 21-game losing streak against ranked teams.

No. 10 West Virginia 68, No. 9 Villanova 66, OT » In Philadelphia, Da'Sean Butler scored 21 points, including the decisive basket with 5.8 seconds left in overtime, to give the Mountaineers the win.

S. Carolina 77, No. 13 Vanderbilt 73 » In Nashville, Tenn., Devan Downey scored 26 points, including a 3-pointer with 1:48 left that broke a 69-all tie in an upset of the Commodores. Sam Muldrow added 20 points as South Carolina ended a six-game skid.